AB0733 Musculo-articular syndrome in patients with Systemic Sclerosis-polymyositis/dermatomyositis overlap syndrome.

Background Systemic Sclerosis-polymyositis/dermatomyositis overlap syndrome (SSc-PM/DM) occurs in 10 to 37% of cases and has great differential diagnostic difficulties. Muscle damage SSc-PM/DM is represented by myositis with primary inflammatory necrotic alterations muscle fibers type PM/DM. Objectives To evaluate joint patients SSc-PM/DM. Methods 112 pts had idiopathic myopathies, which 73 (51 lSSc 22 dSSc, male/female 24/49, mean age 44±14,5 years, average disease’s duration 7 (2;9) years) the standard clinical examination, intramuscular electromyography (IM-EMG) manual testing (MMT-8). Results All polyarthralgia, 40% - arthritis. Damage periarticular tissues formation flexion contractures was observed 70% pts, 16% large joints (knee elbow). X-ray changes hands feet (distal osteoporosis, narrowing spaces, smoothness phalangettes) were all 13% erosions associated osteoarthritis. There noticed significantly frequent development dSSc (p<0.05) high skin score (p<0.05). Osteolysis peculiar SSc detected 23.5% soft tissue calcinosis area phalangettes, metacarpophalangeal – 32% pts. Calcifications, specifically PM/DM, shoulder pelvic girdle, revealed 6% A direct correlation between disease osteolysis Myalgia proximal weakness dysphagia 43% dysphonia 19% Patients a moderate degree (MMT-8 76-115 points) prevailed topped 41% severe disabling functional disorders ≤75 showed 37%, 4% completely immobilized. In 18% PM during physical and/or laboratory examination ≥ 116 points). Analysis IM-EMG confirmed presence process (all decrease motor unit action potential (MUAP) spontaneous activity, polyphasia 93% immunological signs activity: ESR activity (p<0.02), CPK titers (p<0.01), a-Pm-Scl MUAP (p<0.03). Conclusion Muscular clear symptoms, underlying symptom involvement sharp movement intrinsic However, such do not lead complete immobility, as they are combined other manifestations SSc. Articular mainly changes, some common Disclosure Interests None declared